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Home / Archives for Miguel Viveiros

Miguel Viveiros

Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola

  • Autores: Carla Silva, Diana Machado, Isabel Couto, Isabel Portugal, Joao Perdigao, Jorge Ramos, Miguel Viveiros, Nuno Taveira, Pedro Masakidi, Sofia Clemente
  • Ano de Publicação: 2017
  • Journal: Scientific Reports
  • Link: http://www.nature.com/articles/srep42814?WT.feed_name=subjects_infectious-diseases

Tuberculosis (TB) poses a serious public health problem in Angola. No surveillance data on drug resistance is available and nothing is known regarding the genetic diversity and population structure of circulating Mycobacterium tuberculosis strains. Here, we have genotyped and evaluated drug susceptibility of 89 Mycobacterium tuberculosis clinical isolates from Luanda.
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Prevention and control of antimicrobial resistant healthcare associated infections: the Microbiology Laboratory rocks!

  • Autores: Alexandra S. Simões, Cristina Toscano, Elsa Gonçalves, Isabel Couto, Luís V. Lapão, Miguel Viveiros, Pedro Póvoa
  • Ano de Publicação: 2016
  • Journal: Frontiers in Microbiology
  • Link: http://journal.frontiersin.org/article/10.3389/fmicb.2016.00855/full

This paper addresses the role and importance of the Microbiology Laboratory in the prevention and control of healthcare-associated infection and in Antibiotic Stewardship Programs and how it can be leveraged when combined with the use of information systems. Additionally, we critically review some challenges that the Microbiology Laboratory has to deal with, including the selection of analytic methods and the proper use of communication channels with other healthcare services.
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Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages

  • Autores: Adriana Alves, Amelia C. Crampin, Anabela Miranda, Arnab Pain, David Moore, Elizabeth M. Streicher, Erivelton de Oliveira Sousa, Francesc Coll, Indra Bergval, Isabel Portugal, Joao Perdigao, Jody E. Phelan, Judith R. Glynn, Keertan Dheda, Louis Grandjean, Martin L. Hibberd, Miguel Viveiros, Nicolaas C. Gey van Pittius, Patricia Sheen, Paul D. van Helden, Richard M. Anthony, Rob Warren, Rumina Hasan, Ruth McNerney, Samantha L. Sampson, Stefan Panaiotov, Susana Campino, Taane G. Clark, Theolis Barbosa Bessa, Zahra Hasan
  • Ano de Publicação: 2016
  • Journal: BMC Genomics
  • Link: http://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-016-2467-y

Approximately 10 % of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their highly conserved N-terminal domains that incorporate proline-glutamate (PE) and proline-proline-glutamate (PPE) signature motifs. They are hypothesised to be important virulence factors involved with host-pathogen interactions, but their high genetic variability and complexity of analysis means they are typically disregarded in genome studies.
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Fluorimetric Methods for Analysis of Permeability, Drug Transport Kinetics, and Inhibition of the ABCB1 Membrane Transporter

  • Autores: Ana Armada, António Sebastião Rodrigues, Célia Martins, Gabriella Spengler, Joseph Molnar, Leonard Amaral, Miguel Viveiros
  • Ano de Publicação: 2016
  • Journal: Methods in molecular biology
  • Link: http://link.springer.com/protocol/10.1007%2F978-1-4939-3347-1_7

The cell membrane P-glycoprotein (P-gp; MDR1, ABCB1) is an energy-dependent efflux pump that belongs to the ATP-binding cassette (ABC) family of transporters, and has been associated with drug resistance in eukaryotic cells. Multidrug resistance (MDR) is related to an increased expression and function of the ABCB1 (P-gp) efflux pump that often causes chemotherapeutic failure in cancer.
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