Discovery and Characterization of Auxiliary Proteins Encoded by Type 3 Simian T-Cell Lymphotropic Viruses
- Autores: Carpentier A, Dodon MD, Edwards D, Galioot A, Gazzolo L, Journo C, Ko NL, Sinet F, Turpin J, Vandamme A-M
- Ano de Publicação: 2015
- Journal: Journal of Virology
- Link: http://www.ncbi.nlm.nih.gov/pubmed/25355890
Human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 encode auxiliary proteins that play important roles in viral replication, viral latency, and immune escape. The presence of auxiliary protein-encoding open reading frames (ORFs) in HTLV-3, the latest HTLV to be discovered, is unknown. Simian T-cell lymphotropic virus type 3 (STLV-3) is almost identical to HTLV-3. Given the lack of HTLV-3-infected cell lines, we took advantage of STLV-3-infected cells and of an STLV-3 molecular clone to search for the presence of auxiliary transcripts.