Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil
- Autores: Coelho T, Couto I, Machado D, Maschmann R, Ramos D, Rossetti ML, Silva PA, Viveiros M, von Groll A
- Ano de Publicação: 2015
- Journal: Frontiers in Microbiology
- Link: http://www.ncbi.nlm.nih.gov/pubmed/25972842
Drug resistant tuberculosis continues to increase and new approaches for its treatment are necessary. The identification of M. tuberculosis clinical isolates presenting efflux as part of their resistant phenotype has a major impact in tuberculosis treatment. In this work, we used a checkerboard procedure combined with the tetrazolium microplate-based assay (TEMA) to study single combinations between antituberculosis drugs and efflux inhibitors (EIs) against multidrug resistant M. tuberculosis clinical isolates using the fully susceptible strain H37Rv as reference.