Miguel Viveiros is Full Professor with Habilitation in Biomedical Sciences (Speciality Microbiology) in the Unit of Medical Microbiology of the Instituto de Higiene e Medicina Tropical and Global Health and Tropical Medicine from Universidade NOVA de Lisboa.
He has a Bachelor in Sciences with Major in Microbiology, a Master in Sciences in Biotechnology (Chemical Engineering) and a PhD degree in Biology (Microbial Genetics) from the Universidade de Lisboa. In 2012 obtained the Habilitation in Biomedical Sciences (Speciality Microbiology) by the Instituto de Higiene e Medicina Tropical da Universidade Nova de Lisboa.
Currently, is researcher and teacher in Medical Microbiology and President of the Pedagogical Council of the IHMT/UNL, and an invited professor at the Faculdade de Medicina do Rio de Janeiro (Brasil).
His main areas of interest are in support of the mission and institutional strategy of teaching and capacity building for the Community of Portuguese Language Countries (CPLP) in Biomedical Sciences, International Health and Tropical Medicine. Scientific activity devoted to the early diagnosis of active or latent tuberculosis (TB) infections as well as the development of new diagnostic and therapeutic approaches to deal with MDRTB and with other drug resistant bacterial infections. Research mainly focused on tuberculosis and antibiotic resistant infections in support for alternative therapies of incurable diseases such as multidrug resistant tuberculosis and methicillin-vancomycin resistant staphylococcal infections using non-antibiotic adjuvants of the chemotherapy, as well as the early diagnosis of tuberculosis in low-resource countries by new nanotechnology based technologies. Also interested in molecular biology of mycobacteria and immunology of TB.
As Director of the TB Laboratory of the IHMT (since 2001) has contributed to the resolution of the pulmonary TB problem of Lisbon by the generation of complete reports within a period of 15 to 20 days for 10 Hospitals of the TB Task Force of Lisbon. He has led various research projects in those areas (aprox. 2,5M€), supervised and/or co-supervised several postgraduate degrees (3 pos-docs, 7 PhD , 20 MSc students) , and acted as a consultant for the Portuguese National Directorate of Health, CPLP board and Health Ministries, Foundation of Sciences and Technologies of Portugal and ECDC. Founding member and Treasurer of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Mycobacterial Infections (ESGMYC – https://www.escmid.org/index.php?id=897 ).
Member of the evaluation panel of Individual Doctoral and Post-doctoral Grant proposals – area Biomedical Sciences and Basic Medicine -2013-2015 -Fundação para a Ciência e a Tecnologia – Ministério da Educação e Ciência de Portugal. Expert Evaluator for the “MRC South Africa 2013- 2014” calls (area Tuberculosis). Member of the Review and Advisory Panel of the ‘Wellcome Trust Awards”. Ad-hoc reviewer for the expert panel of the The Research Foundation – Flanders (FWO), Belgium and National Agency for Scientific Evaluation (ANEP), Spain. Member of the evaluation panels for the QREN R&D investment proposals of the Ministério da Economia de Portugal. Regular ad-hoc reviewer of several international journal manuscripts (JAC, AAC, PlosOne, IJAA, Tuberculosis, BMC Microbiology, etc) .
Miguel Viveiros is author/co-author of over 120 scientific papers in peer review national and international journals in mycobacteriology, bacteriology, resistance to antibiotics, microbial genetics, molecular epidemiology and immunology.and 19 book chapters, with a Scopus H-index of 33 / Google Scholar H-Index of 37.
Scientific activity devoted to the early diagnosis of active and/or latent tuberculosis (TB) as well as the development of new therapeutic approaches for the treatment of M/XDRTB and other bacterial infections resistant to drugs. Research on TB and antibiotic resistant infections in the perspective of the development of alternative therapies for multi- and extensively drug-resistant tuberculosis and methicillin/vancomycin -resistant staphylococcal infections. Immunology of tuberculosis.
Strong interest in helping Lusophone African countries in the fight against tuberculosis. Close collaboration in teaching and research with Brazil. Expertise in laboratory diagnosis of mycobacterial infections, particularly tuberculosis. Mycobacterial cell wall composition / envelope, mechanisms of resistance to drugs, new antibiotics, antibiotic uptake, efflux pumps, design and development of new antibiotics, flow cytometry. Molecular epidemiology of tuberculosis.
Team: Isabel Couto, Jorge Ramos, Ana Armada, Diana Machado, Sofia Santos Costa
- Pieroni M, Machado D, Azzali E, Santos Costa S, Couto I, Costantino G, Viveiros M. Rational Design and Synthesis of Thioridazine Analogues as Enhancers of the Antituberculosis Therapy. J Med Chem. 2015 Aug 13;58(15):5842-53. doi: 10.1021/acs.jmedchem.5b00428. Epub 2015 Aug 3.
- Coll F, McNerney R, Preston MD, Guerra-Assunção JA, Warry A, Hill-Cawthorne G, Mallard K, Nair M, Miranda A, Alves A, Perdigão J, Viveiros M, Portugal I, Hasan Z, Hasan R, Glynn JR, Martin N, Pain A, Clark TG. Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences. Genome Med. 2015 May 27;7(1):51. doi: 10.1186/s13073-015-0164-0. eCollection 2015.
- Cambau E, Viveiros M, Machado D, Raskine L, Ritter C, Tortoli E, Matthys V, Hoffner S, Richter E, Perez Del Molino ML, Cirillo DM, van Soolingen D, Böttger EC. Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study. J Antimicrob Chemother. 2015 Mar;70(3):686-96. doi: 10.1093/jac/dku438.
- Coll F, McNerney R, Guerra-Assunção JA, Glynn JR, Perdigão J, Viveiros M, Portugal I, Pain A, Martin N, Clark TG. A robust SNP barcode for typing Mycobacterium tuberculosis complex strains. Nature Communications. 2014 Sep 1;5:4812.
- Machado D, Perdigão J, Ramos J, Couto I, Portugal I, Ritter C, Boettger EC, Viveiros M. High-level resistance to isoniazid and ethionamide in multidrug-resistant Mycobacterium tuberculosis of the Lisboa family is associated with inhA double mutations. J Antimicrob Chemother. 2013 Aug;68(8):1728-32. doi: 10.1093/jac/dkt090. Epub 2013 Mar 28.