- Autores: José de la Fuente, Octavio Armas, Luis Sánchez‐Rodríguez, Christian Gortázar, Alexander N. Lukashev, COVID‐BCG Collaborative Working Group
- Ano de Publicação: 2021
- Journal: Wiley Online Library
- Link: https://onlinelibrary.wiley.com/doi/epdf/10.1111/tbed.14097
Current results do not provide conclusive evidence on the effect of BCG vaccination on COVID‐19 alone or in combination with other factors. To address this limitation, in this study we used a citizen science initiative on the COVID‐19 pandemic to collect data worldwide during October 2‐30, 2020 (1,233 individuals) in a structured way for analyzing factors and characteristics of affected individuals in relation to BCG vaccination. For the first time, the results of our study suggested that vaccination with BCG may increase the risk for COVID‐19 at certain age, particularly in individuals vaccinated at childhood. Childhood BCG vaccination increased the likelihood of being diagnosed with COVID‐19 fivefold in COVID‐19 low‐incidence countries and threefold in high‐incidence countries. A reasonable explanation for this effect is the activation of certain innate immunity mechanisms associated with inflammatory reactions. These factors should be considered when analyzing the risks associated with this global pandemic.