IHMT

Instituto de Higiene e Medicina Tropical

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Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad

Abstract Malaria, leishmaniasis and Chagas disease are vector-borne protozoal infections with a disproportionately high impact on the most fragile societies in the world, and despite malaria-focused research gained momentum in the past two decades, both trypanosomiases and leishmaniases remain neglected tropical diseases. Affordable effective drugs remain the mainstay of tackling this burden, but toxicicty, inneficiency […]
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Alphaviruses Detected in Mosquitoes in the North-Eastern Regions of South Africa, 2014 to 2018

Abstract The prevalence and distribution of African alphaviruses such as chikungunya have increased in recent years. Therefore, a better understanding of the local distribution of alphaviruses in vectors across the African continent is important. Here, entomological surveillance was performed from 2014 to 2018 at selected sites in north-eastern parts of South Africa where alphaviruses have […]
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HIV-1-Transmitted Drug Resistance and Transmission Clusters in Newly Diagnosed Patients in Portugal Between 2014 and 2019

The “Treatment for All” program was implemented in many countries with an aim to offer treatment and care to anyone diagnosed with HIV, regardless of the stage of infection (CD4 cell count). In Portugal, this program was implemented in 2015 [World Health Organiztion (WHO), 2021]. The widespread use and increased coverage of antiretroviral therapy (ART) […]
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Anemia in Pregnant Women and Children Aged 6 to 59 Months Living in Mozambique and Portugal: An Overview of Systematic Reviews

Abstract: Introduction: Globally, anemia is still a public health issue faced by people in low and high-income countries. This study gives an overview of published scientific articles related to the prevalence, nutritional indicators, and social determinants of anemia in pregnant women and children aged 6 to 59 months living in Mozambique and Portugal. Methods: We […]
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1,2,4-Trioxolane and 1,2,4,5-Tetraoxane Endoperoxides against Old-World Leishmania Parasites: In Vitro Activity and Mode of Action

Abstract Leishmaniasis remains one of the ten Neglected Tropical Diseases with significant morbidity and mortality in humans. Current treatment of visceral leishmaniasis is difficult due to a lack of effective, non-toxic, and non-extensive medications. This study aimed to evaluate the selectivity of 12 synthetic endoperoxides (1,2,4-trioxolanes; 1,2,4,5-tetraoxanes) and uncover their biochemical effects on Leishmania parasites responsible for […]
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Determinants of Late HIV Presentation at Ndlavela Health Center in Mozambique

Abstract Background: There has been tremendous progress in the fight against HIV worldwide; however, challenges persist in the control of HIV infection. These challenges include the high prevalence of late presenters. There are many disadvantages of late presentation—from reduced survival of the infected person to the risk of transmitting the infection. This research aims to […]
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Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019: A Comparison Between the Populations of Late Presenters and Non-late Presenters

Background: The increased use of antiretroviral therapy (ART) has decreased mortality and morbidity of HIV-1 infected people but increasing levels of HIV drug resistance threatens the success of ART regimens. Conversely, late presentation can impact treatment outcomes, health costs, and potential transmission of HIV. Objective: To describe the patterns of transmitted drug resistance (TDR) and acquired drug […]
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HIV-1 Transmitted drug resistance and transmission clusters in newly diagnosed patients in Portugal between 2014 and 2019

Objective: To describe and analyze Transmitted Drug Resistance (TDR) between 2014 and 2019 in newly infected HIV-1 patients in Portugal and to characterize its transmission networks. Methods: Clinical, socio-epidemiological and risk behavior data was collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. Sequences obtained from drug resistance testing were […]
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Genome-Wide Diversity of Zika Virus: Exploring Spatio-Temporal Dynamics to Guide a New Nomenclature Proposal

Abstract The Zika virus (ZIKV) disease caused a public health emergency of international concern that started in February 2016. The overall number of ZIKV-related cases increased until November 2016, after which it declined sharply. While evaluation of the potential risk and impact of future arbovirus epidemics remains challenging, intensified surveillance efforts along with a scale […]
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Tuberculosis contact investigation in African Portuguese-speaking countries at End TB Strategy era: a scoping review

Abstract Objectives The contact investigation of tuberculosis (TB) index case is one of the critical elements pointed by the WHO to reach the end of the TB epidemic. The scoping review aimed to map out the recommended and the adopted processes applied to active contact investigation of TB index case in African Portuguese-speaking countries (PALOP). Design Scoping […]
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