Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene

• Autores: Afonso A, Alves AC, Castro H, Lopes D, Neto Z, Rosário VD, Tomas AM
• Ano de Publicação: 2010
• Journal: Malaria Journal
• Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Plasmodium+chabaudi+chabaudi+malaria+parasites+can+develop+stable+resistance+to+atovaquone+with+a+mutation+in+the+cytochrome+b+gene

BACKGROUND:
Plasmodium falciparum, has developed resistance to many of the drugs in use. The recommended treatment policy is now to use drug combinations. The atovaquone-proguanil (AP) drug combination, is one of the treatment and prophylaxis options. Atovaquone (ATQ) exerts its action by inhibiting plasmodial mitochondria electron transport at the level of the cytochrome bc1 complex.
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