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Home / Archives for Lopes D

Lopes D

Bis-alkylamineIndolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarialcytostatic and cytocidal activities

  • Autores: Charneira C, Figueiras M, Gut J, Lavrado J, Lopes D, Machado M, Moreira R, Nogueira F, Paulo A, Rosenthal PJ, Santos SA
  • Ano de Publicação: 2014
  • Journal: Journal of Medicinal Chemistry
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/24673163

To get insight into the relevance of targeting hemozoin (Hz) crystals, two isomeric series, N5,N10-bis-alkylamine (2a-k) and N10,O11-bis-alkylamine (3a-k) indolo[3,2-b]quinolines, were evaluated for their in vitro activity against chloroquine (CQ)-resistant and sensitive strains of Plasmodium falciparum.
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Treatment of plasmodium chabaudi parasites with curcumin in combination with antimalarial drugs: Drug interactions and implications on the ubiquitin/proteasome system

  • Autores: Do Rosário V, Gazarini ML, Lindeza A, Lopes D, Machado M, Neto Z
  • Ano de Publicação: 2013
  • Journal: Journal of Parasitology Research
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23691276

Antimalarial drug resistance remains a major obstacle in malaria control. Evidence from Southeast Asia shows that resistance to artemisinin combination therapy (ACT) is inevitable. Ethnopharmacological studies have confirmed the efficacy of curcumin against Plasmodium spp.
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A review of antimalarial plants used in traditional medicine in communities in Portuguese-speaking countries: Brazil, Mozambique, Cape Verde, Guinea-Bissau, São Tomé and Príncipe and Angola.

  • Autores: Amaral AC, Canto-Cavalheiro MM, de Moura DF, Do Rosário VE, Figueiredo P, Lopes D, Machado M, Neto Z, Ramos Ade S, Silva JR
  • Ano de Publicação: 2011
  • Journal: Memorias do Instituto Oswaldo Cruz
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=A+review+of+antimalarial+plants+used+in+traditional+medicine+in+communities+in+Portuguese-Speaking+countries%3A+Brazil%2C+Mozambique%2C+Cape+Verde%2C+Guinea-Bissau%2C+Sao+Tome+and+Principe+and+Angola

The isolation of bioactive compounds from medicinal plants, based on traditional use or ethnomedical data, is a highly promising potential approach for identifying new and effective antimalarial drug candidates.
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SLC40A1 Q248H allele frequencies and associated SLC40A1 haplotypes in three West African population samples.

  • Autores: Albuquerque D, Alvarez M, Arez AP, Lopes D, Loua KM, Manco L, Millimono TS, Nogueira F, Rath SL, Relvas L, Ribeiro ML, Trovoada Mde J, Varandas L
  • Ano de Publicação: 2011
  • Journal: Annals of human biology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=SLC40A1+Q248H+allele+frequencies+and+associated+SLC40A1+haplotypes+in+three+West+African+population+samples.

BACKGROUND:
Ferroportin is a transmembrane protein responsible for iron export from enterocytes and macrophages. Mutation c.744G → T (Q248H), located in exon 6 of the ferroportin gene SLC40A1, is found as a polymorphism in populations of African origin. This mutation has been extensively analysed in African-Americans, but poorly studied in native African populations.
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Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene

  • Autores: Afonso A, Alves AC, Castro H, Lopes D, Neto Z, Rosário VD, Tomas AM
  • Ano de Publicação: 2010
  • Journal: Malaria Journal
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Plasmodium+chabaudi+chabaudi+malaria+parasites+can+develop+stable+resistance+to+atovaquone+with+a+mutation+in+the+cytochrome+b+gene

BACKGROUND:
Plasmodium falciparum, has developed resistance to many of the drugs in use. The recommended treatment policy is now to use drug combinations. The atovaquone-proguanil (AP) drug combination, is one of the treatment and prophylaxis options. Atovaquone (ATQ) exerts its action by inhibiting plasmodial mitochondria electron transport at the level of the cytochrome bc1 complex.
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Karavilagenin C derivatives as antimalarials.

  • Autores: Ferreira MJ, Lopes D, Molnar J, Mulhovo S, Ramalhete C, Rosário VE
  • Ano de Publicação: 2011
  • Journal: Bioorganic & Medicinal Chemistry
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Karavilagenin+C+derivatives+as+antimalarials

Karavilagenin C (1), a cucurbitane-type triterpenoid, previously isolated from the aerial parts of Momordica balsamina, was acylated with different alkanoyl, aroyl and cinnamoyl chlorides/anydrides, yielding ten new mono or diesters, karavoates F (7) and H-P (8-16).
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Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections.

  • Autores: da Cruz FP, Ferreira MJ, Lopes D, Mulhovo S, Prudencio M, Ramalhete C, Rosário VE
  • Ano de Publicação: 2011
  • Journal: Bioorganic & Medicinal Chemistry
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Triterpenoids+as+inhibitors+of+erythrocytic+and+liver+stages+of+Plasmodium+infections

Bioassay-guided fractionation of the methanol extract of Momordica balsamina led to the isolation of two new cucurbitane-type triterpenoids, balsaminol F (1) and balsaminoside B (2), along with the known glycosylated cucurbitacins, cucurbita-5,24-diene-3β,23(R)-diol-7-O-β-D-glucopyranoside (3) and kuguaglycoside A (4). Compound 1 was acylated yielding two new triesters, triacetylbalsaminol F (5) and tribenzoylbalsaminol F (6).
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Evaluation of prevalence’s of pfdhfr and pfdhps mutations in Angola.

  • Autores: Dimbu R., Do Rosário VE, Figueiredo P, Fortes F, Lopes D, Neto Z
  • Ano de Publicação: 2011
  • Journal: Malaria Journal
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Evaluation+of+prevalence%27s+of+pfdhfr+and+pfdhps+mutations+in+Angola.

BACKGROUND:
Malaria is the major cause of morbidity and mortality in Angola. The most vulnerable groups to Plasmodium falciparum infection are pregnant women and children under five years of age.
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Bis-alkylamine quindolone derivatives as new antimalarial leads

  • Autores: Figueiredo P, Gani K, Gut J, Lavrado J, Lopes D, Moreira R, Nobre PA, Paulo A, Rosário VD, Rosenthal PJ, Santos SA
  • Ano de Publicação: 2010
  • Journal: Bioorganic & Medicinal Chemistry Letters
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Bis-alkylamine+quindolone+derivatives+as+new+antimalarial+leads

Quindolone derivatives, designed to target the malaria parasite digestive vacuole and heme detoxification pathway, have been synthesized by reaction with 2-chloro-N,N-diethylethanamine. This reaction gave N,O-, N,N- and O-alkylated products containing one or two basic side-chains. The compounds were evaluated for antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum W2 strain and for cytotoxicity in HepG2 A16 […]
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