Chitosan-based nanoparticles as drug delivery systems for doxorubicin: optimization and modelling

In the present work, two drug delivery systems were produced by encapsulating doxorubicin into chitosan and O-HTCC (ammonium-quaternary derivative of chitosan) nanoparticles. The results show that doxorubicin release is independent of the molecular weight and is higher at acidic pH (4.5) than at physiological pH.
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Iron oxide nanoparticles stabilized with a bilayer of oleic acid for magnetic hyperthermia and MRI applications

Autores: Borges JP, Carvalho A, Coutinho JT, Ferreira IMM, Laia CAT, Novo C, Pereira LCJ, Soares PIP
Ano de Publicação: 2016
Journal: Applied Surface Science
Link: http://www.sciencedirect.com/science/article/pii/S0169433216309709

Iron oxide nanoparticles (Fe3O4, IONPs) are promising candidates for several biomedical applications such as magnetic hyperthermia and as contrast agents for magnetic resonance imaging (MRI). However, their colloidal stability in physiological conditions hinders their application requiring the use of biocompatible surfactant agents.
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Ferreira IMM

Chitosan-based nanoparticles as drug delivery systems for doxorubicin: optimization and modelling

Iron oxide nanoparticles stabilized with a bilayer of oleic acid for magnetic hyperthermia and MRI applications

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