In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate
- Autores: Bruce Russell, Carla Judice, Daniel Y. Bargieri, Fabio T. M. Costa, François Nosten, Irene S. Soares, Juliana A. Leite, Laurent Rénia, Letusa Albrecht, Marcelo U. Ferreira, Marcus V. G. Lacerda, Najara Bittencourt, Pedro Cravo, Renato B. Machado, Rossarin Suwanarusk, Stefanie C. P. Lopes, Taizy Leda, Yun Shan Goh
- Ano de Publicação: 2018
- Journal: Malaria Journal
- Link: https://malariajournal.biomedcentral.com/articles/10.1186/s12936-017-2144-x
Technical limitations for culturing the human malaria parasite Plasmodium vivax have impaired the discovery of vaccine candidates, challenging the malaria eradication agenda. The immunogenicity of the M2 domain of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) antigen cloned from the Plasmodium yoelii murine parasite, has been previously demonstrated.
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