1,2,4-Trioxolane and 1,2,4,5-Tetraoxane Endoperoxides against Old-World Leishmania Parasites: In Vitro Activity and Mode of Action

• Autores: Andreia Mendes, Ana Armada, Lília I. L. Cabral, Patrícia S. M. Amado, Lenea Campino, Maria L. S. Cristiano, Sofia Cortes
• Ano de Publicação: 2022
• Journal: Mdpi
• Link: https://www.mdpi.com/1424-8247/15/4/446

Abstract Leishmaniasis remains one of the ten Neglected Tropical Diseases with significant morbidity and mortality in humans. Current treatment of visceral leishmaniasis is difficult due to a lack of effective, non-toxic, and non-extensive medications. This study aimed to evaluate the selectivity of 12 synthetic endoperoxides (1,2,4-trioxolanes; 1,2,4,5-tetraoxanes) and uncover their biochemical effects on Leishmania parasites responsible for […]
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