An original deal for new molecule: reversal of efflux pump activity, a rational strategy to combat gram-negative resistant bacteria.
- Autores: Amaral L, Fanning S, Pagès JM
- Ano de Publicação: 2011
- Journal: Current Medicinal Chemistry
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=n+original+deal+for+new+molecule%3A+reversal+of+efflux+pump+activity%2C+a+rational+strategy+to+combat+gram-negative+resistant+bacteria
The worldwide dissemination of «multi-drug resistant» (MDR) pathogens has severely reduced the efficacy of our antibiotic arsenal and increased the frequency of therapeutic failure. MDR bacteria over-express efflux pumps and this active mechanism can extrude all classes of antibiotics from the cell.