• Skip to primary navigation
  • Skip to content
  • Skip to footer
  • Estudantes
    • Webmail
    • Moodle
    • Ensino à Distância
    • NetP@
    • Biblioteca
    • Escola Doutoral
    • Serviços Académicos
    • Trabalhar no IHMT
  • Staff
    • Webmail
    • Área de Docentes
    • Área de Não-Docentes

IHMT

Instituto de Higiene e Medicina Tropical

PortuguêsEnglishFrançaisDeutschEspañol

Universidade Nova de Lisboa

  • Ensino
    • Doutoramentos
    • Mestrados
    • Ensino à Distância
    • Cursos de Especialização
    • Cursos de Curta Duração
    • Apoio ao Desenvolvimento
  • Investigação
    • GHTM
  • Doenças Tropicais
    • Glossário
    • Consulta do Viajante
    • Museu
      • Peça do Mês
    • Vídeos
    • MosquitoWeb
  • Unidades de Ensino e de Investigação
  • 5º Congresso Nacional de Medicina Tropical
Home / Publicações / Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.

Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.

  • Autores: Afonso C, Almeida AP, Frischknecht F, Gardner R, Gomes-Santos CS, Henriques R, Itoe MA, Moita LF, Mota MM, Raquel H, Sepúlveda N, Simões PD
  • Ano de Publicação: 2012
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Highly+Dynamic+Host+Actin+Reorganization+around+Developing+Plasmodium+Inside+Hepatocytes

Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown. Here we show that highly dynamic hepatocyte actin reorganization events occur around developing Plasmodium berghei parasites inside human hepatoma cells. Actin reorganization is most prominent between 10 to 16 hours post infection and depends on the actin severing and capping protein, gelsolin. Live cell imaging studies also suggest that the hepatocyte cytoskeleton may contribute to parasite elimination during Plasmodium development in the liver.

Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.

  • Autores: Afonso C, Almeida AP, Frischknecht F, Gardner R, Gomes-Santos CS, Henriques R, Itoe MA, Moita LF, Mota MM, Raquel H, Sepúlveda N, Simões PD
  • Ano de Publicação: 2012
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Highly+Dynamic+Host+Actin+Reorganization+around+Developing+Plasmodium+Inside+Hepatocytes

Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown. Here we show that highly dynamic hepatocyte actin reorganization events occur around developing Plasmodium berghei parasites inside human hepatoma cells. Actin reorganization is most prominent between 10 to 16 hours post infection and depends on the actin severing and capping protein, gelsolin. Live cell imaging studies also suggest that the hepatocyte cytoskeleton may contribute to parasite elimination during Plasmodium development in the liver.

Footer

  • Sobre o IHMT
  • Organização
  • Docentes e Investigadores
  • Serviços Académicos
  • Recursos Humanos
  • Trabalhar no IHMT
  • Instrumentos de Gestão
  • Associação de Alunos e Amigos
  • Parcerias
  • Biblioteca
  • Biobanco GHTM-IHMT – Biotropical Resources
  • Ensino
  • Investigação
  • Cooperação e Desenvolvimento
  • Qualidade

Contactos

Rua da Junqueira, 100
1349-008 Lisboa
Portugal
+351 213 652 600
+351 213 632 105

Contactos dos Serviços

Marcação de consultas:
+351 213 652 630/90
+351 213 627 553
medicina.viagens@ihmt.unl.pt

Subscrever newsletter

Follow us

  • Facebook
  • LinkedIn
  • YouTube
© Copyright 2021 IHMT-UNL Todos os Direitos Reservados.
  • Universidade Nova de Lisboa
  • Fundação para a Ciência e a Tecnologia

    Project UID/Multi/04413/2013

We use cookies to ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are happy with it.Ok