The added effect of thioridazine in the treatment of drug-resistant tuberculosis.
- Autores: Abbate E, Amaral L, Udwadia Z, Van Soolingen D
- Ano de Publicação: 2012
- Journal: The International Journal of Tuberculosis and Lung Disease
- Link: http://docstore.ingenta.com/cgi-bin/ds_deliver/1/u/d/ISIS/86433297.1/iuatld/ijtld/2012/00000016/00000012/art00026/0BD6A0E92239C33F14585566579DF2734D5804CD9C.pdf?link=http://www.ingentaconnect.com/error/delivery&format=pdf
The review by Grosset et al. in a recent issue of the
Journal is highly interesting, and rightly pictures a
bright horizon for the improved treatment of tuberculosis. However, there are alternative compounds
that can already provide considerable relief in compassionate
application of treatment for multidrugr
esistant and extensively drug-resistant tuberculosis
(MDR/XDR-TB) in the short term, and may offer an
important additional effect in treatment regimens due
to a special working mechanism, such as effl ux pump
inhibition.
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