Challenges in Antibody Development against Tn and Sialyl-Tn Antigens

• Autores: Barbas A, Carrascal MA, Delannoy P, Loureiro LR, Novo C, Ramalho JS, Videira PA
• Ano de Publicação: 2015
• Journal: Biomolecules
• Link: http://www.mdpi.com/2218-273X/5/3/1783

The carbohydrate antigens Tn and sialyl-Tn (STn) are expressed in most carcinomas and usually absent in healthy tissues. These antigens have been correlated with cancer progression and poor prognosis, and associated with immunosuppressive microenvironment. Presently they are used in clinical trials as therapeutic vaccination, but with limited success due to their low immunogenicity.
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