IHMT

Instituto de Higiene e Medicina Tropical

Home / Archives for 2015

2015

Vírus Zika: Revisão para Clínicos

O vírus Zika é um flavivírus filogeneticamente relacionado com o vírus dengue, vírus da febre-amarela e vírus do Nilo Ocidental. É considerado uma arbovirose emergente transmitida por mosquitos do género Aedes. A sua descoberta deu-se em 1947 na floresta Zika no Uganda, isolado em macaco Rhesus que servia de isco para estudo do vírus da febre-amarela.
Ler mais

Ebola impact on african health systems entails a quest for more international and local resilience: the case of african portuguese speaking countries

Ebola epidemics have shown to have significant impacts on many aspects of healthcare systems. African countries have been facing many difficulties while addressing Ebola epidemics, moreover due to both lack of resources and fragmented involvement of national and international entities. The participation of multiple organizations has created serious problems of coordination of aid and the operation of that aid on the ground. This paper aims at addressing the impact of Ebola epidemics on African health systems, with a special focus on the definition of impact mitigation guidelines and the role of resilience. The example of Portuguese speaking countries is presented.
Ler mais

Use of services for prevention of mother-to-child transmission in Angola: a retrospective analysis

After a long civil war that destroyed much of the country’s health infrastructure, Angola faced the challenge of reconstruction while fighting HIV/AIDS. This paper analyses recent progress in access and use of prevention of mother-to-child transmission (PMTCT) services in Angola
Ler mais

Polymorphisms in Plasmodium falciparum K13-propeller in Angola and Mozambique after the introduction of the ACTs

We report the presence of SNPs in Plasmodium falciparum K13-propeller gene in two African countries, Angola and Mozambique, where malaria is a serious public health problem. Samples were collected before and after ACT introduction as first-line treatment. In each country 50 samples collected before and 50 after ACT introduction were analysed.
Ler mais

Synthesis and antimalarial evaluation of prodrugs of novel fosmidomycin analogues

The continuous development of drug resistance by Plasmodium falciparum, the agent responsible for the most severe forms of malaria, creates the need for the development of novel drugs to fight this disease. Fosmidomycin is an effective antimalarial and potent antibiotic, known to act by inhibiting the enzyme 1-deoxy-d-xylulose-5-phosphate reductoisomerase (DXR), essential for the synthesis of isoprenoids in eubacteria and plasmodia, but not in humans.
Ler mais

N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials

In a follow-up study to our reports of N-cinnamoylated chloroquine and quinacrine analogues as promising dual-stage antimalarial leads with high in vitro potency against both blood-stage Plasmodium falciparum and liver-stage Plasmodium berghei, we decided to investigate the effect of replacing the cinnamoyl moiety with other acyl groups. Thus, a series of N-acylated analogues were synthesized, and their activities against blood- and liver-stage Plasmodium spp. were assessed along with their in vitro cytotoxicities.
Ler mais

Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype

A series of 3-piperidin-4-yl-1H-indoles with building block diversity was synthesized based on a hit derived from an HTS whole-cell screen against Plasmodium falciparum. Thirty-eight compounds were obtained following a three-step synthetic approach and evaluated for anti-parasitic activity.
Ler mais

The quinolone-hydroxyquinoline tautomerism in quinolone 3-esters; preserving the 4-oxoquinoline structure to retain antimalarials activity

Recent publications report in vitro activity of quinolone 3-esters against the bc1 protein complex of Plasmodium falciparum and the parasite. Docking studies performed in silico at the yeast Qo site established a key role for the 4-oxo and N–H groups in drug-target interactions. Thus, the possibility of 4-oxoquinoline/4-hydroxyquinoline tautomerism may impact in pharmacologic profiles and should be investigated.
Ler mais

Social inequality, health policies and the training of physicians, nurses and dentists in Brazil and in Portugal

This study analyzes the production of scientific knowledge on Health Inequalities (HI) and its use in policies of education of dentists, nurses and physicians in Brazil and Portugal.
Ler mais