Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype
- Autores: Coelho L, Lukens AK, Mazitschek R, Moreira R, Nogueira F, Paulo A, Santos SA, Wirth DF
- Ano de Publicação: 2015
- Journal: Journal of Medicinal Chemistry
- Link: http://www.ncbi.nlm.nih.gov/pubmed/26295174
A series of 3-piperidin-4-yl-1H-indoles with building block diversity was synthesized based on a hit derived from an HTS whole-cell screen against Plasmodium falciparum. Thirty-eight compounds were obtained following a three-step synthetic approach and evaluated for anti-parasitic activity.