Sequencing of E2 and NS5A regions of HCV genotype 3a in Brazilian patients with chronic hepatitis

• Autores: Azevedo RS, Carrilho FJ, Gonçalves L, Malta Fde M, Medeiros-Filho JE, Pinho JR, Silva LC
• Ano de Publicação: 2010
• Journal: Memorias do Instituto Oswaldo Cruz
• Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Sequencing+of+E2+and+NS5A+regions+of+HCV+genotype+3a+in+Brazilian+patients+with+chronic+hepatitis

Hepatitis C virus (HCV) is a major cause of liver disease throughout the world. The NS5A and E2 proteins of HCV genotype 1 were reported to inhibit the double-stranded (ds) RNA-dependent protein kinase (PKR), which is involved in the cellular antiviral response induced by interferon (IFN). The response to IFN therapy is quite different between […]
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