Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
- Autores: Alves A, Coll F, Guerra-Assunção JA, Hill-Cawthorne G, Mallard K, McNerney R, Miranda A, Nair M, Preston MD, Viveiros M, Warry A
- Ano de Publicação: 2015
- Journal: Genome Medicine
- Link: http://www.ncbi.nlm.nih.gov/pubmed/26019726
Mycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease control. Current molecular tests examine limited numbers of mutations, and although whole genome sequencing approaches could fully characterise DR, data complexity has restricted their clinical application.