Support of the Infectivity of Hepatitis Delta Virus Particles by the Envelope Proteins of Different Genotypes of Hepatitis B Virus
- Autores: Abe K, Cunha C, Freitas N, Gudima SO, Menne S
- Ano de Publicação: 2014
- Journal: Journal of Virology
- Link: http://jvi.asm.org/content/88/11/6255.abstract
This study examined how the envelope proteins of 25 variants of hepatitis B virus (HBV) genotypes A to I support hepatitis delta virus (HDV) infectivity. The assembled virions bore the same HDV ribonucleoprotein and differed only by the HBV variant-specific envelope proteins coating the particles. The total HDV yields varied within a 122-fold range. A residue Y (position 374) in the HDV binding site was identified as critical for HDV assembly.