Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74
- Autores: Amaral L, Chaki S, Christensen JB, Dasgupta A, Dastidar SG, Hendricks O, Kristiansen JE, Mukherjee S
- Ano de Publicação: 2010
- Journal: International Journal of Antimicrobial Agents
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Thioridazine+protects+the+mouse+from+a+virulent+infection+by+Salmonella+enterica+serovar+Typhimurium+74
When administered to mice at doses of 100microg/mouse and 200microg/mouse, thioridazine (TDZ) significantly protected animals from the lethality produced by a virulent strain of Salmonella enterica serovar Typhimurium and reduced the number of bacteria retrieved from the spleen, liver and heart blood.