Biological activity of twenty-three hydantoin derivatives on intrinsic efflux pump system of Salmonella enterica serovar Enteritidis NCTC 13349.
- Autores: Amaral L, Evaristo M, Handzlik J, Kiec-Kononowicz K, Machado L, Molnar J, Spengler G, Viveiros M
- Ano de Publicação: 2011
- Journal: In vivo
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Biological+activity+of+twenty-three+hydantoin+derivatives+on+intrinsic+efflux+pump+system+of+Salmonella+enterica+serovar+Enteritidis+NCTC+13349.
Hydantoin derivatives have important biochemical and pharmacological properties. In the present study, 23 hydantoin compounds were evaluated for their efflux-modulating effects in Salmonella enterica serovar Enteritidis NCTC 13349 using real-time fluorimetry based on the intracellular accumulation of ethidium bromide (EB), a universal substrate of efflux pumps.