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Instituto de Higiene e Medicina Tropical

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Martins Mde L

Enhanced activity of antifungal drugs using natural phenolics against yeast strains of Candida and Cryptococcus.

AIMS:
Determine whether certain, natural phenolic compounds enhance activity of commercial antifungal drugs against yeast strains of Candida and Cryptococcus neoformans.
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Enhancement of commercial antifungal agents by Kojic Acid.

Natural compounds that pose no significant medical or environmental side effects are potential sources of antifungal agents, either in their nascent form or as structural backbones for more effective derivatives. Kojic acid (KA) is one such compound. It is a natural by-product of fungal fermentation commonly employed by food and cosmetic industries.
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