Thioridazine cures extensively drug-resistant tuberculosis (XDR-TB) and the need for global trials is now!
- Autores: Amaral L, Boeree MJ, Gillespie SH, Udwadia ZF, Van Soolingen D
- Ano de Publicação: 2010
- Journal: International Journal of Antimicrobial Agents
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Thioridazine+cures+extensively+drug-resistant+tuberculosis+(XDR-TB)+and+the+need+for+global+trials+is+now
Thioridazine (TDZ) has been shown to have in vitro activity against multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis, to promote the killing of intracellular MDR and XDR strains and to cure the mouse of antibiotic-susceptible and -resistant pulmonary tuberculosis (TB) infections.