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Instituto de Higiene e Medicina Tropical

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Future Virology

Order and disorder in viral proteins: new insights into an old paradigm.

The conventional dogma stating that proteins must fold into a well-defined structure In order to display biological function is being challenged everyday as new data emerge on the relevance of disordered regions and intrinsically disordered proteins. Viral proteins in particular can benefit greatly from the conformational flexibility granted by partially folded or unfolded protein segments.
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Virus and non-coding RNAs: stars in the host-virus interaction game

In the past few years, noncoding RNAs (ncRNAs) have emerged as key modulators of the transcriptional and post-transcriptional control of a variety of cellular processes such as development, signaling, homeostasis and oncogenesis. Like their host cells, many viruses produce ncRNAs.
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