• Autores: Campino L, de Sousa B, Farrell N, Madureira J, Maia C, Marques M, Ramos CIV, Santana-Marques MG
• Ano de Publicação: 2013
• Journal: Inorganic Chemistry
• Link: http://pubs.acs.org/doi/abs/10.1021/ic401067d

[Cu(II)(dppz)2(AcOO)]+ and [Zn(II)(dppz)2]2+ bind DNA by intercalation and covalent binding modes. A loss of a dppz unit, which occurs only when DNA is present, justifies such dual binding mode.

The proposed interaction mechanism results from combined biophysical data from thermal denaturation, CD, rheometry, AFM and QTof-ESI-MS. DNA saturation occurs for copper at about half the concentration of zinc, apparently due to the increased ability of Cu(II) to distort to a more planar structure.