Elucidating in vitro and in vivo phenotypic behaviour of L. infantum/L. major natural hybrids
- Autores: Albuquerque-Wendt A, Campino L, Carvalho M, Cortes S, de Freitas L A R, dos-Santos W L C, Lima I A, Maia C
- Ano de Publicação: 2018
- Journal: Parasitology
- Link: https://doi.org/10.1017/S0031182018001993
The clinical manifestation and course of Leishmania infections depend on factors such as species, virulence and host-immunity. Although trypanosomatids are considered to have clonal propagation, genetic hybridization has produced successful natural hybrid lineages. Hybrids displaying strong selective advantages may have an impact on pathogenesis and the ecoepidemiology of leishmaniasis. Thus, characterization of phenotypic properties of Leishmania hybrids could bring significant insight into the biology, infectivity, pathogenicity and transmission dynamics of these atypical strains.