Diversity of Pneumocystis jirovecii Across Europe: A Multicentre Observational Study

• Autores: Alanio A, Bretagne S, Calderon EJ, Desnos-Ollivier M, Di Cave D, Dupont D, Gits-Muselli M, Guigue N, Hamprecht A, Hauser PM, Helweg-Larsen J, Kicia M, Lagrou K, Lengerova M, Matos O, Melchers WJG, Morio F, Nevez G, Totet A, White LP
• Ano de Publicação: 2017
• Journal: EBioMedicine
• Link: https://www.ncbi.nlm.nih.gov/pubmed/28705464

Pneumocystis jirovecii is an airborne human-specific ascomycetous fungus responsible for Pneumocystis pneumonia (PCP) in immunocompromised patients, affecting >500,000 patients per year (www.gaffi.org). The understanding of its epidemiology is limited by the lack of standardised culture. Recent genotyping data suggests a limited genetic diversity of P. jirovecii. The objective of the study was to assess the diversity of P. jirovecii across European hospitals and analyse P. jirovecii diversity in respect to clinical data obtained from the patients.
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