N-cinnamoylation of antimalarial classics: quinacrine analogues with decreased toxicity and dual-stage activity
- Autores: Albuquerque I, Gomes A, Gomes P, Machado M, Nogueira F, Perez B, Prudencio M, Teixeira C
- Ano de Publicação: 2014
- Journal: Chemmedchem
- Link: http://www.ncbi.nlm.nih.gov/pubmed/24474655
Plasmodium falciparum, the causative agent of the most lethal form of malaria, is becoming increasingly resistant to most available drugs. A convenient approach to combat parasite resistance is the development of analogues of classical antimalarial agents, appropriately modified in order to restore their relevance in antimalarial chemotherapy.