Horizontal gene transfer from human host to HIV-1 reverse transcriptase confers drug resistance and partly compensates for replication deficits
- Autores: De Baets G, Dekeersmaeker N, Li G, Megens S, Moutschen M, Rousseau F, Schrooten Y, Schymkowitz J, Vaira D, Van Laethem K, Vandamme AM
- Ano de Publicação: 2014
- Journal: Virology
- Link: http://www.ncbi.nlm.nih.gov/pubmed/24889250
We investigated the origin and the effect of insertion D67D-THGERDLGPA within HIV-1 RT from a patient failing antiviral therapy. The insertion developed within the context of pre-existing NRTI and NNRTI mutations (M41L, L210W, T215Y and N348I).