HIV-1 protease mutation 82M contributes to phenotypic resistance to protease inhibitors in subtype G.

• Autores: Camacho RJ, Covens K, Palma AC, Snoeck J, Van Laethem K, Vandamme AM
• Ano de Publicação: 2012
• Journal: Journal of Antimicrobial Chemotherapy
• Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=HIV-1+protease+mutation+82M+contributes+to+phenotypic+resistance+to+protease+inhibitors+in+subtype+G

OBJECTIVES:
The purpose of this study was the qualitative and quantitative assessment of the in vitro effect of HIV-1 protease (PR) mutation 82M on replication capacity and susceptibility to the eight clinically available PR inhibitors (PIs).
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