Aids

An ancestral HIV-2/simian immunodeficiency virus peptide with potent HIV-1 and HIV-2 fusion inhibitor activity

Autores: Barroso H, Borrego P, Calado R, Marcelino JM, Pereira P, Quintas A, Taveira N
Ano de Publicação: 2013
Journal: Aids
Link: http://www.ncbi.nlm.nih.gov/pubmed/23324659

To produce new fusion inhibitor peptides for HIV-1 and HIV-2 based on ancestral envelope sequences.
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Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia.

Autores: Baptista AP, Cavaleiro R, Fernandes S, Foxall RB, Gomes P, Marcelino JM, Soares RS, Sousa AE., Taveira N, Tendeiro R, Victorino RM
Ano de Publicação: 2012
Journal: Aids
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Memory+B-cell+depletion+is+a+feature+of+HIV-2+infection+even+in+the+absence+of+detectable+viremia

OBJECTIVE:
Memory B-cell loss has long been recognized as an important contributor to HIV immunodeficiency. HIV-2 infection, which is characterized by a slow rate of progression to AIDS and reduced to undetectable viremia, provides a unique model to investigate B-cell disturbances.
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Resistance to antibody neutralization in HIV-2 infection occurs in late stage disease and is associated with X4 tropism.

Autores: Antunes F, Barroso H, Borrego P, Doroana M, Família C, Maltez F, Marcelino JM, Nilsson C, Quintas A, Taveira N
Ano de Publicação: 2012
Journal: Aids
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Resistance+to+antibody+neutralization+in+HIV-2+infection+occurs+in+late+stage+disease+and+is+associated+with+X4+tropism

OBJECTIVES:
To characterize the nature and dynamics of the neutralizing antibody (NAb) response and escape in chronically HIV-2 infected patients.
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Lack of evidence for the selection of E138 mutations by first-generation non-nucleoside reverse transcriptase inhibitors in patients infected with HIV-1 non-B subtypes

Autores: Abecasis AB, Theys K, Van Laethem K
Ano de Publicação: 2015
Journal: Aids
Link: http://www.ncbi.nlm.nih.gov/pubmed/25909833

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Aids

An ancestral HIV-2/simian immunodeficiency virus peptide with potent HIV-1 and HIV-2 fusion inhibitor activity

Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia.

Resistance to antibody neutralization in HIV-2 infection occurs in late stage disease and is associated with X4 tropism.

Lack of evidence for the selection of E138 mutations by first-generation non-nucleoside reverse transcriptase inhibitors in patients infected with HIV-1 non-B subtypes

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