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Home / Archives for AIDS Research and Human Retroviruses

AIDS Research and Human Retroviruses

Novel multiregion hybridization assay for the identification of the most prevalent genetic forms of the human immunodeficiency virus type 1 circulating in Portugal

  • Autores: Esteves A, Freitas FB, Parreira R, Piedade J
  • Ano de Publicação: 2013
  • Journal: AIDS Research and Human Retroviruses
  • Link: http://online.liebertpub.com/doi/abs/10.1089/aid.2012.0025

The most efficient method for HIV-1 genetic characterization involves full-genome sequencing, but the associated costs, technical features, and low throughput preclude it from being routinely used for the analysis of large numbers of viral strains. Multiregion hybridization assays (MHA) represent an alternative for a consistent genetic analysis of large numbers of viral strains. Classically, MHA rely on the amplification by real-time PCR of several regions scattered along the HIV-1 genome, and on their characterization with clade-specific TaqMan probes (also known as hydrolysis probes).
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Escape from neutralization is a frequent event in HIV-2 infection and is strongly associated with X4 tropism

  • Autores: Antunes F, Barroso H, Borrego P, Doroana M, Marcelino JM, Nilsson C, Novo C, Taveira N
  • Ano de Publicação: 2010
  • Journal: AIDS Research and Human Retroviruses
  • Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=1&SID=W1nslz6EeRqf8Bzyzm3&page=1&doc=1

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Short communication: Prevalence of HIV type 1 transmitted drug resistance in Slovenia: 2005-2010

  • Autores: Abecasis AB, Karner P, Lunar MM, Maver PJ, Pecavar B, Poljak M, Seme K, Tomazic J, Vidmar L, Vovko TD, Židovec Lepej S
  • Ano de Publicação: 2013
  • Journal: AIDS Research and Human Retroviruses
  • Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552160/

Slovenia is a small European country with a total of 547 HIV-infected individuals cumulatively reported by the end of 2011. However, the estimated incidence rate of HIV infections increased from 7.0 per million in 2003 to 26.8 per million in 2011. In this study, we assessed the prevalence of transmitted drug resistance (TDR) in the past 6 years (2005–2010) and analyzed the time trend of the proportion of men having sex with men (MSM) and HIV-1 subtype B among newly diagnosed individuals in a 15-year period (1996–2010) in Slovenia.
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Appearance of a single amino acid insertion at position 33 in HIV type 1 protease under a lopinavir-containing regimen, associated with reduced protease inhibitor susceptibility.

  • Autores: Camacho RJ, Detsika MG, Hatzakis A, Imbrechts S, Lazanas M, Lu L, Magiorkinis E, Magiorkinis G, Molla A, Paraskevis D, Pilot-Matias T, Van Laethem K, Vandamme AM
  • Ano de Publicação: 2011
  • Journal: AIDS Research and Human Retroviruses
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Appearance+of+a+Single+Amino+Acid+Insertion+at+Position+33+in+HIV+Type+1+Protease+Under+a+Lopinavir-Containing+Regimen%2C+Associated+with+Reduced+Protease+Inhibitor+Susceptibility

HIV drug resistance is a multifactorial phenomenon and constitutes a major concern as it results in therapy failure. The aim of this study was to assess the impact of an amino acid insertion identified at position 33 of the protease gene, derived from samples from three patients under lopinavir therapy, on viral fitness and protease inhibitor (PI) resistance.
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Molecular Epidemiological Analysis of Paired pol/env Sequences from Portuguese HIV Type 1 Patients

  • Autores: Abecasis AB, Camacho RJ, Carvalho AP, Costa I, Diogo I, Gomes P, Martins A, Portuguese Hiv-1 Resistance Study Group
  • Ano de Publicação: 2011
  • Journal: AIDS Research and Human Retroviruses
  • Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=5&SID=P2WA5hwy5j35Sqjoq2z&page=1&doc=1

The advent of new therapeutic approaches targeting env and the search for efficient anti-HIV-1 vaccines make it necessary to identify the number of recombinant forms using genomic regions that were previously not frequently sequenced.
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