• Skip to primary navigation
  • Skip to main content
  • Skip to footer
  • Pessoal
    • Webmail
    • Área de Docentes
    • Área de Não-Docentes
  • Estudantes
    • Webmail
    • Moodle
    • NetP@
    • Biblioteca
    • Escola Doutoral
    • Serviços Académicos
    • Trabalhar no IHMT

IHMT

Instituto de Higiene e Medicina Tropical

  • O Instituto
    • Missão
    • História
    • Mensagem do Diretor
    • Órgãos de governo
    • Docentes e investigadores
    • Unidades de Ensino e de Investigação
  • Ensino
    • Doutoramentos
    • Mestrados
    • Cursos de Especialização
    • Formação transversal
    • Cursos de Curta Duração
    • Ensino à Distância
    • Apoio ao Desenvolvimento
    • Serviços académicos
  • Investigação
    • Centro GHTM
    • Unidade de Clínica Tropical
    • Unidade de Microbiologia Médica
    • Unidade de Parasitologia Médica
    • Unidade de Saúde Pública Global
    • Serviço de Interesse Comum
    • Biobanco
    • Centro Colaborador da OMS
    • Publicações
  • Serviços e gestão
    • Biblioteca
    • Sistema de Qualidade
    • Estatutos e regulamentos
    • Relatórios
    • Contratos públicos
    • Recursos humanos
      • Concursos e bolsas
      • Contratos
      • Avaliação e Desempenho
        • Processo Eleitoral da Comissão Paritária
      • Mobilidade
  • Doenças Tropicais
    • Consulta do Viajante
    • Glossário
    • Museu
    • Vídeos
    • MosquitoWeb
  • Comunidade
    • Cooperação e Desenvolvimento
    • Formação
    • Parcerias
  • Contactos
  • Português
  • English
Home / Archives for Gomes P

Gomes P

N-cinnamoylation of antimalarial classics: quinacrine analogues with decreased toxicity and dual-stage activity

  • Autores: Albuquerque I, Gomes A, Gomes P, Machado M, Nogueira F, Perez B, Prudencio M, Teixeira C
  • Ano de Publicação: 2014
  • Journal: Chemmedchem
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/24474655

Plasmodium falciparum, the causative agent of the most lethal form of malaria, is becoming increasingly resistant to most available drugs. A convenient approach to combat parasite resistance is the development of analogues of classical antimalarial agents, appropriately modified in order to restore their relevance in antimalarial chemotherapy.
Ler mais

N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials

  • Autores: Gomes A, Gomes P, Lobo L, Machado M, Nogueira F, Prudencio M, Teixeira C
  • Ano de Publicação: 2015
  • Journal: Chemmedchem
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/26038181

In a follow-up study to our reports of N-cinnamoylated chloroquine and quinacrine analogues as promising dual-stage antimalarial leads with high in vitro potency against both blood-stage Plasmodium falciparum and liver-stage Plasmodium berghei, we decided to investigate the effect of replacing the cinnamoyl moiety with other acyl groups. Thus, a series of N-acylated analogues were synthesized, and their activities against blood- and liver-stage Plasmodium spp. were assessed along with their in vitro cytotoxicities.
Ler mais

The SIGLIC System for Improving the Access to Surgery in Portugal

  • Autores: Gomes P, Lapão LV
  • Ano de Publicação: 2010
  • Journal: Studies in health technology and informatics
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=The+SIGLIC+System+for+Improving+the+Access+to+Surgery+in+Portugal

This paper describes the design and definitions of an information system (SIGLIC) to support a new integrated management program (SIGA) to improve the access to surgery in Portugal. SIGIC, the Ministry of Health’s agency responsible for access to surgery management, started re-thinking the system in 2005 by re-defining key processes and workflows. The designed information […]
Ler mais

Evolution of the human immunodeficiency virus type 2 envelope in the first years of infection is associated with the dynamics of the neutralizing antibody response

  • Autores: Barroso H, Bártolo I, Borrego P, Calado R, Cavaco-Silva P, Família C, Gomes P, Leitner T, Marcelino JM, Quintas A, Rocha C, Rosado L, Skar H, Taveira N
  • Ano de Publicação: 2013
  • Journal: Retrovirology
  • Link: http://www.retrovirology.com/content/10/1/110

Differently from HIV-1, HIV-2 disease progression usually takes decades without antiretroviral therapy and the majority of HIV-2 infected individuals survive as elite controllers with normal CD4+ T cell counts and low or undetectable plasma viral load. Neutralizing antibodies (Nabs) are thought to play a central role in HIV-2 evolution and pathogenesis. However, the dynamic of the Nab response and resulting HIV-2 escape during acute infection and their impact in HIV-2 evolution and disease progression remain largely unknown. Our objective was to characterize the Nab response and the molecular and phenotypic evolution of HIV-2 in association with Nab escape in the first years of infection in two children infected at birth.
Ler mais

Toward the discovery of inhibitors of babesipain-1, a Babesia bigemina cysteine protease: In vitro evaluation, homology modeling and molecular docking studies

  • Autores: Antunes S, Domingos A, Gomes JRB, Gomes P, Gonçalves LM, Perez B, Teixeira C
  • Ano de Publicação: 2013
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/24129820

Babesia bigemina is a protozoan parasite that causes babesiosis, a disease with a world-wide distribution in mammals, principally affecting cattle and man. The unveiling of the genome of B. bigemina is a project in active progress that has already revealed a number of new targets with potential interest for the design of anti-babesiosis drugs. In this context, babesipain-1 has been identified as a proteolytically active enzyme whose three-dimensional structure has not been resolved yet, but which is known to be inhibited by cysteine proteases inhibitors such as E64, ALLN, leupeptin, and vinyl sulfones
Ler mais

Mutations selected in HIV-2-infected patients failing a regimen including atazanavir

  • Autores: Aleixo MJ, Camacho RJ, Cavaco-Silva J, Cunha C, Faria D, Gomes P, Goncalves MF, Valadas E, Van Laethem K, Vandamme AM
  • Ano de Publicação: 2013
  • Journal: Journal of Antimicrobial Chemotherapy
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/22977160

To investigate mutations selected in viruses from HIV-2-infected patients failing a highly active antiretroviral treatment (HAART) regimen including atazanavir/ritonavir.
Ler mais

Origin and Epidemiological History of HIV-1 CRF14_BG

  • Autores: Abecasis AB, Barroso H, Bártolo I, Borrego P, Camacho R, Gomes P, McCutchan F, Taveira N
  • Ano de Publicação: 2011
  • Journal: PLoS One
  • Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=26&SID=P2WA5hwy5j35Sqjoq2z&page=1&doc=1

Background: CRF14_BG isolates, originally found in Spain, are characterized by CXCR4 tropism and rapid disease progression. This study aimed to identify the origin of CRF14_BG and reconstruct its epidemiological history based on new isolates from Portugal.
Ler mais

Novel potent metallocenes against liver stage malaria

  • Autores: Cabrita E, da Cruz FP, Do Rosário VE, Gomes P, Gut J, Matos J, Moreira R, Nogueira F, Prudencio M, Rosenthal PJ
  • Ano de Publicação: 2012
  • Journal: Antimicrobial Agents and Chemotherapy
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Novel+potent+metallocenes+against+liver+stage+malaria.

Novel conjugates of the antimalarial drug primaquine (compound 1) with ferrocene, named primacenes, have been synthesized and screened for their activities against blood stage and liver stage malaria in vitro and host-vector transmission in vivo.
Ler mais

Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia.

  • Autores: Baptista AP, Cavaleiro R, Fernandes S, Foxall RB, Gomes P, Marcelino JM, Soares RS, Sousa AE., Taveira N, Tendeiro R, Victorino RM
  • Ano de Publicação: 2012
  • Journal: Aids
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Memory+B-cell+depletion+is+a+feature+of+HIV-2+infection+even+in+the+absence+of+detectable+viremia

OBJECTIVE:
Memory B-cell loss has long been recognized as an important contributor to HIV immunodeficiency. HIV-2 infection, which is characterized by a slow rate of progression to AIDS and reduced to undetectable viremia, provides a unique model to investigate B-cell disturbances.
Ler mais

The SIGLIC system for improving the access to surgery in Portugal.

  • Autores: Gomes P, Lapão LV
  • Ano de Publicação: 2011
  • Journal: Electronic Journal of Information Systems Evaluation
  • Link: https://www.researchgate.net/publication/290541531_The_SIGLIC_system_for_improving_the_access_to_surgery_in_Portugal

This paper describes the design and first results of an information system (SIGLIC) that supports the new integrated management program (SIGA) to improve the access to surgery in Portugal.
Ler mais

  • Go to page 1
  • Go to page 2
  • Go to Next Page »

Footer

INSTITUTO DE HIGIENE E
MEDICINA TROPICAL
UNIVERSIDADE NOVA DE LISBOA
Rua da Junqueira, 100 1349-008 Lisboa
T +351 213 652 600
geral@ihmt.unl.pt

Consulta do Viajante e Medicina Tropical
T +351 213 652 630
T +351 213 652 690
T +351 91 182 37 48
T +351 91 182 44 67
medicina.viagens@ihmt.unl.pt

Ensino
Investigação
Medicina Tropical
Cooperação

Siga-nos

  • Facebook
  • LinkedIn
  • YouTube

Receber a “newsletter”

© Copyright 2023 IHMT-UNL Todos os Direitos Reservados.
  • Universidade Nova de Lisboa
  • Fundação para a Ciência e a Tecnologia

    Project UID/Multi/04413/2013