Measuring efflux and permeability in mycobacteria
- Autores: Ainsa JA, Rodrigues L, Viveiros M
- Ano de Publicação: 2015
- Journal: Methods in molecular biology
- Link: http://www.ncbi.nlm.nih.gov/pubmed/25779319
The intrinsic resistance of mycobacteria to most antimicrobial agents is mainly attributed to the synergy between their relatively impermeable cell wall and efflux systems. The mycobacterial cell wall is rich in lipids and polysaccharides making a compact envelope that limits drug uptake.