IHMT

Instituto de Higiene e Medicina Tropical

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Andrei IR

Rapid, laser-induced conversion of 20-hydroxyecdysone and its diacetonide — experimental set-up of a system for photochemical transformation of bioactive substances.

BACKGROUND:
Photochemical transformation of certain bioactive compounds for the purpose of obtaining derivatives with increased bioactivity is a prospective area of synthetic chemistry. Ecdysteroids, analogs of the insect molting hormone, which can also exert several beneficial effects in mammals including humans, contain an enone moiety in their B ring, and, as such, are good candidates for photochemical transformations.
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Direct modification of bioactive phenothiazines by exposure to laser radiation.

Whereas exposure of combinations of a phenothiazine and bacterium to incoherent UV increases the activity of the phenothiazine, exposure of the phenothiazine alone does not yield an increase of its activity. Because the laser beam energy is greater than that produced by the incoherent UV sources, exposure of phenothiazines to specific lasers may yield molecules with altered activities over that of the unexposed parent.
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Optical investigation of medicine solutions in micro-droplets form at interaction with laser radiation.

One of the alternatives to the existing medicines and treatment procedures in fighting multi drug resistance (MDR) is strengthening the effects of medicines by modifying their molecular structures through exposure to laser radiation.
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