Trypanosoma cruzi I and IV Stocks from Brazilian Amazon Are Divergent in Terms of Biological and Medical Properties in Mice
- Autores: Bahia MT, Costa Magalhaes LK, de Oliveira Guerra JA, de Ornelas Toledo MJ, dos Reis D, Gomes ML, Gruendling AP, Margioto Teston AP, Marques de Araújo S, Monteiro WM, Silveira H, Vale Barbosa MdG
- Ano de Publicação: 2013
- Journal: Plos Neglected Tropical Diseases
- Link: http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002069
In the Brazilian Amazon, clinical and epidemiological frameworks of Chagas disease are very dissimilar in relation to the endemic classical areas of transmission, possibly due to genetic and biological characteristics of the circulating Trypanosoma cruzi stocks. Twenty six T. cruzi stocks from Western Amazon Region attributed to the TcI and TcIV DTUs were comparatively studied in Swiss mice to test the hypothesis that T. cruzi clonal structure has a major impact on its biological and medical properties.