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Home / Archives for Plos Neglected Tropical Diseases

Plos Neglected Tropical Diseases

Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy.

  • Autores: Alvarez C, de Almeida Kruschewsky R, Decanine D, Galvão-Castro B, Gotuzzo E, Khouri R, López G, Menezes SM, Moens B, Silva-Santos G, Talledo M, Van Weyenbergh J, Vandamme AM
  • Ano de Publicação: 2012
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Ascorbic+Acid+Has+Superior+Ex+Vivo+Antiproliferative%2C+Cell+Death-Inducing+and+Immunomodulatory+Effects+over+IFN-alpha+in+HTLV-1-Associated+Myelopathy

BACKGROUND:
Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind controlled clinical trials. Moderate yet similar clinical benefit has been demonstrated for IFN-α and high-dose ascorbic acid (AA) monotherapy in a large open clinical trial.
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Trypanosoma cruzi I and IV Stocks from Brazilian Amazon Are Divergent in Terms of Biological and Medical Properties in Mice

  • Autores: Bahia MT, Costa Magalhaes LK, de Oliveira Guerra JA, de Ornelas Toledo MJ, dos Reis D, Gomes ML, Gruendling AP, Margioto Teston AP, Marques de Araújo S, Monteiro WM, Silveira H, Vale Barbosa MdG
  • Ano de Publicação: 2013
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002069

In the Brazilian Amazon, clinical and epidemiological frameworks of Chagas disease are very dissimilar in relation to the endemic classical areas of transmission, possibly due to genetic and biological characteristics of the circulating Trypanosoma cruzi stocks. Twenty six T. cruzi stocks from Western Amazon Region attributed to the TcI and TcIV DTUs were comparatively studied in Swiss mice to test the hypothesis that T. cruzi clonal structure has a major impact on its biological and medical properties.
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Mucosal Leishmaniasis caused by Leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian Amazon.

  • Autores: Amato V, Barbosa Md, Coelho LI, Ferreira LC, Gama P, Guerra JA, Moura A, Prestes SR, Silveira H
  • Ano de Publicação: 2011
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Mucosal+Leishmaniasis+caused+by+Leishmania+(Viannia)+braziliensis+and+Leishmania+(Viannia)+guyanensis+in+the+Brazilian+Amazon

BACKGROUND:
Leishmania (Viannia) braziliensis is a parasite recognized as the most important etiologic agent of mucosal leishmaniasis (ML) in the New World. In Amazonia, seven different species of Leishmania, etiologic agents of human Cutaneous Leishmaniasis, have been described. Isolated cases of ML have been described for several different species of Leishmania: L. (V.) panamensis, L. (V.) guyanensis and L. (L.) amazonensis.
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Multilocus sequence typing (MLST) for lineage assignment and high resolution diversity studies in Trypanosoma cruzi.

  • Autores: Acosta N, Bhattacharyya T, Carrasco HJ, Diosque P, Lewis MD, Llewellyn MS, Mauricio IL, Messenger LA, Miles MA, Yeo M
  • Ano de Publicação: 2011
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Multilocus+sequence+typing+(MLST)+for+lineage+assignment+and+high+resolution+diversity+studies+in+Trypanosoma+cruzi

BACKGROUND:
Multilocus sequence typing (MLST) is a powerful and highly discriminatory method for analysing pathogen population structure and epidemiology. Trypanosoma cruzi, the protozoan agent of American trypanosomiasis (Chagas disease), has remarkable genetic and ecological diversity. A standardised MLST protocol that is suitable for assignment of T. cruzi isolates to genetic lineage and for higher resolution diversity studies has not been developed.
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Research priorities for neglected infectious diseases in Latin America and the Caribbean region

  • Autores: Arevalo J, Boelaert M, Carrasco HJ, Correa-Oliveira R, Do Rosário V, Dujardin JC, Garcia L, Gotuzzo E, Gyorkos TW, Herrera S, Kalergis AM, Kouri G, Larraga V, Lutumba P, Macias Garcia MA, Manrique-Saide PC, Modabber F, Nieto A, Olesen OF, Pluschke G, Robello C, Rojas de Arias A, Rumbo M, Santos Preciado JI, Sundar S, Torres J, Torrico F, Van der Stuyft P, Victoir K
  • Ano de Publicação: 2010
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/21049009

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Comparative microsatellite typing of new world leishmania infantum reveals low heterogeneity among populations and its recent old world origin.

  • Autores: Alam MZ, Cupolillo E, Feliciangeli MD, Ferreira GE, Kuhls K, Mauricio IL, Miles MA, Oddone R, Schönian G, Wirth T
  • Ano de Publicação: 2011
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Comparative+microsatellite+typing+of+new+world+Leishmania+infantum+reveals+low+heterogeneity+among+populations+and+its+recent+old+world+origin.

Leishmania infantum (syn. L. chagasi) is the causative agent of visceral leishmaniasis (VL) in the New World (NW) with endemic regions extending from southern USA to northern Argentina.
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Vaccines for the leishmaniases: proposals for a research agenda.

  • Autores: Costa CH, de Brito EC Jr, Maruyama SR, Peters NC, Santos IK, Working Group on Research Priorities for Development of Leishmaniasis Vaccines
  • Ano de Publicação: 2011
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Vaccines+for+the+Leishmaniases%3A+Proposals+for+a+research+agenda.

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Duffy negative antigen is no longer a barrier to Plasmodium vivax–molecular evidences from the African West Coast (Angola and Equatorial Guinea).

  • Autores: Arez AP, Benito A, Berzosa P, Cano J, de Sousa B, Dias F, Do Rosário VE, Figueiredo J, Mendes C, Mora VG
  • Ano de Publicação: 2011
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Duffy+negative+antigen+is+no+longer+a+barrier+to+Plasmodium+vivax+%E2%80%93+molecular+evidences+from+the+African+west+coast+(Angola+and+Equatorial+Guinea).

BACKGROUND:
Plasmodium vivax shows a small prevalence in West and Central Africa due to the high prevalence of Duffy negative people. However, Duffy negative individuals infected with P. vivax have been reported in areas of high prevalence of Duffy positive people who may serve as supply of P. vivax strains able to invade Duffy negative erythrocytes. We investigated the presence of P. vivax in two West African countries, using blood samples and mosquitoes collected during two on-going studies.
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Impact of a Dengue Outbreak Experience in the Preventive Perceptions of the Community from a Temperate Region: Madeira Island, Portugal

  • Autores: Antunes L, Gonçalves L, Nazareth T, Porto G, Seixas G, Silva AC, Sousa CA, Teodósio R
  • Ano de Publicação: 2015
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25767886

The ability to effectively modify behaviours is increasingly relevant to attain and maintain a good health status. Current behaviour-change models and theories present two main approaches for (healthier) decision-making: one analytical/logical, and one experiential/emotional/intuitive.
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