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Home / Archives for Monteiro WM

Monteiro WM

Trypanosoma cruzi IV causing outbreaks of acute Chagas disease and infections by different haplotypes in the Western Brazilian Amazonia.

  • Autores: Barbosa Md, Borges L, de Sá AR, Gomes ML, Guerra JA, Magalhaes LK, Monteiro WM, Pires I, Silveira H, Toledo MJ
  • Ano de Publicação: 2012
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Trypanosoma+cruzi+IV+Causing+Outbreaks+of+Acute+Chagas+Disease+and+Infections+by+Different+Haplotypes+in+the+Western+Brazilian+Amazonia.

BACKGROUND:
Chagas disease is an emergent tropical disease in the Brazilian Amazon Region, with an increasing number of cases in recent decades. In this region, the sylvatic cycle of Trypanosoma cruzi transmission, which constitutes a reservoir of parasites that might be associated with specific molecular, epidemiological and clinical traits, has been little explored.
Ler mais

. In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon

  • Autores: Alecrim MG, Brasil LW, Chehuan YF, Costa JS, Costa MR, Lacerda MV, Melo GC, Monteiro WM, Nogueira F, Silveira H
  • Ano de Publicação: 2013
  • Journal: Malaria Journal
  • Link: http://www.malariajournal.com/content/12/1/226

Chloroquine (CQ) and primaquine (PQ) are still the drugs of choice to treat Plasmodium vivax malaria in many endemic areas, Brazil included. There is in vivo evidence for the P. vivax resistance to CQ in the Brazilian Amazon, where the increase in the proportion of P. vivax malaria parallels the increase of unusual clinical complications related to this species. In this study, in vitro CQ and mefloquine (MQ)-susceptibility of P. vivax isolates from the Western Brazilian Amazon was tested using the double-site enzyme-linked lactate dehydrogenase immunodetection (DELI) assay.
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Plasmodium vivax chloroquine resistance and anemia in the western Brazilian Amazon

  • Autores: Alecrim MG, Brasil LW, Costa MR, Lacerda MV, Marques MM, Monteiro WM, Nascimento MT, Nogueira F, Reyes-Lecca RC, Santana Filho FS, Silveira H, Vieira JL
  • Ano de Publicação: 2014
  • Journal: Antimicrob Agents Chemother
  • Link: http://aac.asm.org/content/early/2013/10/22/AAC.02279-12

In Latin America, data on chloroquine (CQ)-resistant Plasmodium vivax is limited, even with the current research efforts to sustain an efficient malaria control program in all these endemic countries, where malaria still is a major public health issue.
Ler mais

Trypanosoma cruzi I and IV Stocks from Brazilian Amazon Are Divergent in Terms of Biological and Medical Properties in Mice

  • Autores: Bahia MT, Costa Magalhaes LK, de Oliveira Guerra JA, de Ornelas Toledo MJ, dos Reis D, Gomes ML, Gruendling AP, Margioto Teston AP, Marques de Araújo S, Monteiro WM, Silveira H, Vale Barbosa MdG
  • Ano de Publicação: 2013
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002069

In the Brazilian Amazon, clinical and epidemiological frameworks of Chagas disease are very dissimilar in relation to the endemic classical areas of transmission, possibly due to genetic and biological characteristics of the circulating Trypanosoma cruzi stocks. Twenty six T. cruzi stocks from Western Amazon Region attributed to the TcI and TcIV DTUs were comparatively studied in Swiss mice to test the hypothesis that T. cruzi clonal structure has a major impact on its biological and medical properties.
Ler mais

In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon

  • Autores: Alecrim MG, Brasil LW, Chehuan YF, Costa JS, Costa MR, Lacerda MV, Melo GC, Monteiro WM, Nogueira F, Silveira H
  • Ano de Publicação: 2013
  • Journal: Malaria Journal
  • Link: http://www.malariajournal.com/content/12/1/226

Chloroquine (CQ) and primaquine (PQ) are still the drugs of choice to treat Plasmodium vivax malaria in many endemic areas, Brazil included. There is in vivo evidence for the P. vivax resistance to CQ in the Brazilian Amazon, where the increase in the proportion of P. vivax malaria parallels the increase of unusual clinical complications related to this species. In this study, in vitro CQ and mefloquine (MQ)-susceptibility of P. vivax isolates from the Western Brazilian Amazon was tested using the double-site enzyme-linked lactate dehydrogenase immunodetection (DELI) assay.
Ler mais

Biological behavior of Trypanosoma cruzi stocks obtained from the State of Amazonas, Western Brazilian Amazon, in mice.

  • Autores: Barbosa Md, Ferreira LC, Guerra JA, Magalhaes LK, Monteiro WM, Oliveira JC, Silveira H, Toledo MJ
  • Ano de Publicação: 2012
  • Journal: Revista Da Sociedade Brasileira De Medicina Tropical
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Biological+behavior+of+Trypanosoma+cruzi+stocks+obtained+from+the+State+of+Amazonas%2C+Western+Brazilian+Amazon%2C+in+mice

INTRODUCTION:
The biological diversity of circulating Trypanosoma cruzi stocks in the Amazon region most likely plays an important role in the peculiar clinic-epidemiological features of Chagas disease in this area.
Ler mais

Trypanosoma cruzi IV causing outbreaks of acute Chagas disease and infections by different haplotypes in the Western Brazilian Amazonia.

  • Autores: Barbosa Md, Borges L, de Sá AR, Gomes ML, Guerra JA, Magalhaes LK, Monteiro WM, Pires I, Silveira H, Toledo MJ
  • Ano de Publicação: 2012
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Trypanosoma+cruzi+IV+Causing+Outbreaks+of+Acute+Chagas+Disease+and+Infections+by+Different+Haplotypes+in+the+Western+Brazilian+Amazonia.

BACKGROUND:
Chagas disease is an emergent tropical disease in the Brazilian Amazon Region, with an increasing number of cases in recent decades. In this region, the sylvatic cycle of Trypanosoma cruzi transmission, which constitutes a reservoir of parasites that might be associated with specific molecular, epidemiological and clinical traits, has been little explored. The objective of this work is to genetically characterize stocks of T. cruzi from human cases, triatomines and reservoir mammals in the State of Amazonas, in the Western Brazilian Amazon.
Ler mais

Chagas disease in the State of Amazonas: history, epidemiological evolution, risks of endemicity and future perspectives

  • Autores: Bemfica Barbosa Ferreira JM, Costa Magalhaes LK, de Oliveira Guerra JA, Fe NF, Goncalves Santana RA, Lima Arcanjo AR, Monteiro WM, Mota DT, Silveira H, Vale Barbosa MdG
  • Ano de Publicação: 2015
  • Journal: Revista Da Sociedade Brasileira De Medicina Tropical
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/26061368

Chagas disease (CD) is a parasitic infection that originated in the Americas and is caused by Trypanosoma cruzi. In the last few years, the disease has spread to countries in North America, Asia and Europe due to the migration of Latin Americans. In the Brazilian Amazon, CD has an endemic transmission, especially in the Rio Negro region, where an occupational hazard was described for piaçaveiros (piassaba gatherers).
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Trypanosoma cruzi strain Tcl is associated with chronic Chagas disease in the Brazilian Amazon

  • Autores: Barbosa MDV, Barbosa-Ferreira JM, Coelho LIDRC, da Silva GAV, de Brito FR, Guerra JAO, Maciel MG, Magalhaes LK, Magalhaes LKC, Monteiro WM, Prestes SR, Santana RAG, Silveira H
  • Ano de Publicação: 2014
  • Journal: Parasites & Vectors
  • Link: http://www.parasitesandvectors.com/content/7/1/267

The aim of this study was to characterize Trypanosoma cruzi in patients with chronic Chagas disease in the State of Amazonas, Brazil.
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Plasmodium vivax Chloroquine Resistance and Anemia in the Western Brazilian Amazon

  • Autores: Alecrim MGC, Brasil LW, Costa MRF, Lacerda MVG, Marques MM, Monteiro WM, Nascimento MTS, Nogueira F, Reyes-Lecca RC, Santana Filho FS, Silveira H, Vieira JLF
  • Ano de Publicação: 2014
  • Journal: Antimicrobial Agents and Chemotherapy
  • Link: http://aac.asm.org/content/early/2013/10/22/AAC.02279-12

In Latin America, data on chloroquine (CQ)-resistant Plasmodium vivax is limited, even with the current research efforts to sustain an efficient malaria control program in all these endemic countries, where malaria still is a major public health issue. This study estimated in vivo CQ-resistance in uncomplicated patients with P. vivax in use of CQ and primaquine simultaneously, in the Brazilian Amazon. From a total of 135 enrolled subjects, who accomplished the 28-day follow-up, parasitological failure was observed in 7 (5.2%) patients, in which plasmatic CQ and desethylchloroquine (DCQ) concentrations were above 100ng/dL.
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