The genealogical population dynamics of HIV-1 in a large transmission chain: bridging within and among host evolutionary rates
- Autores: Baele G, Derdelinckx I, Drummond A, Lemey P, Rambaut A, Suchard MA, Van Laethem K, Van Wijngaerden E, Vandamme AM, Vrancken B
- Ano de Publicação: 2014
- Journal: PLoS Computational Biology
- Link: http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003505
Transmission lies at the interface of human immunodeficiency virus type 1 (HIV-1) evolution within and among hosts and separates distinct selective pressures that impose differences in both the mode of diversification and the tempo of evolution. In the absence of comprehensive direct comparative analyses of the evolutionary processes at different biological scales, our understanding of how fast within-host HIV-1 evolutionary rates translate to lower rates at the between host level remains incomplete.