Bis-alkylamine quindolone derivatives as new antimalarial leads
- Autores: Figueiredo P, Gani K, Gut J, Lavrado J, Lopes D, Moreira R, Nobre PA, Paulo A, Rosário VD, Rosenthal PJ, Santos SA
- Ano de Publicação: 2010
- Journal: Bioorganic & Medicinal Chemistry Letters
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Bis-alkylamine+quindolone+derivatives+as+new+antimalarial+leads
Quindolone derivatives, designed to target the malaria parasite digestive vacuole and heme detoxification pathway, have been synthesized by reaction with 2-chloro-N,N-diethylethanamine. This reaction gave N,O-, N,N- and O-alkylated products containing one or two basic side-chains. The compounds were evaluated for antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum W2 strain and for cytotoxicity in HepG2 A16 […]
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