Whole genome re-sequencing identifies a mutation in an ABC transporter (mdr2) in a Plasmodium chabaudi clone with altered susceptibility to antifolate drugs?
- Autores: Cravo P, Henriques G, Hunt P, Martinelli A
- Ano de Publicação: 2011
- Journal: International Journal for Parasitology
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Whole+genome+re-sequencing+identifies+a+mutation+in+an+ABC+transporter+(mdr2)+in+a+Plasmodium+chabaudi+clone+with+altered+susceptibility+to+antifolate+drugs%3F.
In malaria parasites, mutations in two genes of folate biosynthesis encoding dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) modify responses to antifolate therapies which target these enzymes.