Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities
- Autores: Albuquerque IS, Amewu R, Capela R, Gut J, Lopes F, Marti F, Meireles P, Miranda D, Moreira R, Mota MM, Nogueira F, O’Neill PM, Oliveira R, Paiva I, Prudencio M, Rosenthal PJ
- Ano de Publicação: 2013
- Journal: ACS Medicinal Chemistry Letters
- Link: http://www.ncbi.nlm.nih.gov/pubmed/24900781
In a search for effective compounds against both the blood- and liver-stages of infection by malaria parasites with the ability to block the transmission of the disease to mosquito vectors, a series of hybrid compounds combining either a 1,2,4-trioxane or 1,2,4,5-tetraoxane and 8-aminoquinoline moieties were synthesized and screened for their antimalarial activity.