Expression and characterization of the Babesia bigemina cysteine protease BbiCPL1
- Autores: Do Rosário VE, Domingos A, Martins TM
- Ano de Publicação: 2012
- Journal: Acta Tropica
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Expression+and+characterization+of+the+Babesia+bigemina+cysteine+protease+BbiCPL1.
BbiCPL1 was the first papain-like cysteine protease from a piroplasm to be identified with proteolytic activity. Here we report the improved production of the active recombinant enzyme, and the biochemical characterization of this potential drug target.