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Home / Archives for Experimental Parasitology

Experimental Parasitology

Identification of papain-like cysteine proteases from the bovine piroplasm Babesia bigemina and evolutionary relationship of piroplasms C1 family of cysteine proteases.

  • Autores: Do Rosário VE, Domingos A, Martins TM
  • Ano de Publicação: 2011
  • Journal: Experimental Parasitology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Identification+of+papain-like+cysteine+proteases+from+the+bovine+piroplasm+Babesia+bigemina+and+evolutionary+relationship+of+piroplasms+C1+family+of+cysteine+proteases.

Papain-like cysteine proteases have been shown to have essential roles in parasitic protozoa and are under study as promising drug targets. Five genes were identified by sequence similarity search to be homologous to the cysteine protease family in the ongoing Babesia bigemina genome sequencing project database and were compared with the annotated genes from the complete bovine piroplasm genomes of Babesia bovis, Theileria annulata, and Theileria parva.
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In vitro drug susceptibility of Leishmania infantum isolated from humans and dogs

  • Autores: Campino L, Henriques S, Maia C, Marques M, Nunes M, Rolão N
  • Ano de Publicação: 2013
  • Journal: Experimental Parasitology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23747751

Visceral leishmaniasis (VL) caused by parasites of Leishmania donovani complex is a severe human disease which often leads to death if left untreated. Domestic dogs are the main reservoir hosts for zoonotic human visceral infection caused by Leishmania infantum. In the absence of effective human and dog vaccines, the only feasible way to treat and control leishmaniasis is through the use of suitable medications.
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Trypanosoma brucei: immunisation with plasmid DNA encoding invariant surface glycoprotein gene is able to induce partial protection in experimental African trypanosomiasis.

  • Autores: Atouguia J, De Sousa KP, Lança AS, Monteiro GA, Prazeres DM, Silva MS
  • Ano de Publicação: 2011
  • Journal: Experimental Parasitology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Trypanosoma+brucei%3A+Immunisation+with+plasmid+DNA+encoding+invariant+surface+glycoprotein+gene+is+able+to+induce+partial+protection+in+experimental+African+trypanosomiasis.

Trypanosoma brucei is the etiological agent responsible for African trypanosomiasis, an infectious pathology which represents a serious problem of public health and economic losses in Sub-Saharan Africa.
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Dynamics of cytokines and immunoglobulins serum profiles in primary and secondary Cryptosporidium parvum infection: Usefulness of Luminex® xMAP technology

  • Autores: Borrego M, Codices V, de Sousa B, Lopes T, Martins C, Matos O, Novo C
  • Ano de Publicação: 2013
  • Journal: Experimental Parasitology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23178641

Infection by Cryptosporidium parvum triggers a complex array of innate and adaptive cell mediated immune response, playing an important role in controlling the infection. To date, there are no studies applying the Luminex® xMAP technology to determine profiles of cytokines and immunoglobulins in the context of an infection by C. parvum. In this study, we analyzed these immune mediators in the serum of immunocompetent mice inoculated with C. parvum oocysts, using Luminex, to understand how the immune system responds to an infection by this parasite.
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Generation of an antibody that recognizes Plasmodium chabaudi cysteine protease (chabaupain-1) in both sexual and asexual parasite life cycle and evaluation of chabaupain-1 vaccine potential

  • Autores: Almeida AJ, Antunes S, Armada A, Custodio A, Domingos A, Gazarini M, Gonçalves LM, Rodrigues A, Rosário VE, Santos-Gomes G, Silveira H
  • Ano de Publicação: 2013
  • Journal: Experimental Parasitology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23830988

Malaria cysteine proteases have been shown to be immunogenic and are being exploited as serodiagnostic markers, drug and vaccine targets. Several Plasmodium spp. cysteine proteases have been described and the best characterized of these are the falcipains, a family of papain-family enzymes. Falcipain-2 and falcipain-3 act in concert with other proteases to hydrolyze host erythrocyte hemoglobin in the parasite food vacuole.
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Trypanosoma brucei: Immunisation with plasmid DNA encoding invariant surface glycoprotein gene is able to induce partial protection in experimental African trypanosomiasis.

  • Autores: Atouguia J, de Sousa KF, Lanca ASC, Monteiro GA, Prazeres DMF, Silva MS
  • Ano de Publicação: 2011
  • Journal: Experimental Parasitology
  • Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=40&SID=2CbhBUDoSw8ZkFBEQLW&page=1&doc=1

Trypanosoma brucei is the etiological agent responsible for African trypanosomiasis, an infectious pathology which represents a serious problem of public health and economic losses in Sub-Saharan Africa.
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