Plasmodium vivax Chloroquine Resistance and Anemia in the Western Brazilian Amazon
- Autores: Alecrim MGC, Brasil LW, Costa MRF, Lacerda MVG, Marques MM, Monteiro WM, Nascimento MTS, Nogueira F, Reyes-Lecca RC, Santana Filho FS, Silveira H, Vieira JLF
- Ano de Publicação: 2014
- Journal: Antimicrobial Agents and Chemotherapy
- Link: http://aac.asm.org/content/early/2013/10/22/AAC.02279-12
In Latin America, data on chloroquine (CQ)-resistant Plasmodium vivax is limited, even with the current research efforts to sustain an efficient malaria control program in all these endemic countries, where malaria still is a major public health issue. This study estimated in vivo CQ-resistance in uncomplicated patients with P. vivax in use of CQ and primaquine simultaneously, in the Brazilian Amazon. From a total of 135 enrolled subjects, who accomplished the 28-day follow-up, parasitological failure was observed in 7 (5.2%) patients, in which plasmatic CQ and desethylchloroquine (DCQ) concentrations were above 100ng/dL.