Simultaneous RNA quantification of human and retroviral genomes reveals intact interferon signaling in HTLV-1-infected CD4+ T cell lines.
- Autores: Bittencourt A, Farré L, Galvão-Castro B, Gotuzzo E, Khouri R, López G, Moens B, Pannecouque C, Talledo M, Van Weyenbergh J, Vandamme AM
- Ano de Publicação: 2012
- Journal: Virology Journal
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Simultaneous+RNA+quantification+of+human+and+retroviral+genomes+reveals+intact+interferon+signaling+in+HTLV-1-infected+CD4%2B+T+cell+lines.
IFN-α contributes extensively to host immune response upon viral infection through antiviral, pro-apoptotic, antiproliferative and immunomodulatory activities. Although extensively documented in various types of human cancers and viral infections, controversy exists in the exact mechanism of action of IFN-α in human immunodeficiency virus type 1 (HIV-1) and human T-lymphotropic virus type 1 (HTLV-1) retroviral infections.