Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy.
- Autores: Alvarez C, de Almeida Kruschewsky R, Decanine D, Galvão-Castro B, Gotuzzo E, Khouri R, López G, Menezes SM, Moens B, Silva-Santos G, Talledo M, Van Weyenbergh J, Vandamme AM
- Ano de Publicação: 2012
- Journal: Plos Neglected Tropical Diseases
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Ascorbic+Acid+Has+Superior+Ex+Vivo+Antiproliferative%2C+Cell+Death-Inducing+and+Immunomodulatory+Effects+over+IFN-alpha+in+HTLV-1-Associated+Myelopathy
Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind controlled clinical trials. Moderate yet similar clinical benefit has been demonstrated for IFN-α and high-dose ascorbic acid (AA) monotherapy in a large open clinical trial.