Malaria: looking for selection signatures in the human PKLR gene region
- Autores: Amorim A, Arez AP, Do Rosário VE, Fernandes N, Gusmão L, Machado P, Manco L, Miranda J, Pereira R, Ribeiro L, Rocha AM
- Ano de Publicação: 2010
- Journal: British journal of haematology
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Malaria%3A+looking+for+selection+signatures+in+the+human+PKLR+gene+region
The genetic component of susceptibility to malaria is both complex and multigenic and the better-known protective polymorphisms are those involving erythrocyte-specific structural proteins and enzymes. In vivo and in vitro data have suggested that pyruvate kinase deficiency, which causes a nonspherocytic haemolytic anaemia, could be protective against malaria severity in humans, but this hypothesis remains […]
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