Chitosan-based nanoparticles as drug delivery systems for doxorubicin: optimization and modelling
- Autores: Borges JP, Ferreira IMM, Novo C, Silva JC, Soares PIP, Sousa AI
- Ano de Publicação: 2016
- Journal: Carbohydrate Polymers
- Link: http://www.sciencedirect.com/science/article/pii/S0144861716302570
In the present work, two drug delivery systems were produced by encapsulating doxorubicin into chitosan and O-HTCC (ammonium-quaternary derivative of chitosan) nanoparticles. The results show that doxorubicin release is independent of the molecular weight and is higher at acidic pH (4.5) than at physiological pH.